Evaluating the current state of Mendelian randomization studies: a protocol for a systematic review on methodological and clinical aspects using neurodegenerative disorders as outcome

Abstract Background Mendelian randomization (MR) is fast becoming a popular method to judge causality from routinely conducted observational studies. However, stringent underlying statistical assumptions, missing biological information, and high sample size requirement might make it prone to misuse....

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Hauptverfasser:	Sandeep Grover, Fabiola Del Greco M., Inke R. König
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2018-09-01
Schriftenreihe:	Systematic Reviews
Schlagworte:	Mendelian randomization Instrumental variable Observational epidemiology Genome-wide association study Summary data Pleiotropy
Online-Zugang:	http://link.springer.com/article/10.1186/s13643-018-0809-3
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