Evaluating the current state of Mendelian randomization studies: a protocol for a systematic review on methodological and clinical aspects using neurodegenerative disorders as outcome

Abstract Background Mendelian randomization (MR) is fast becoming a popular method to judge causality from routinely conducted observational studies. However, stringent underlying statistical assumptions, missing biological information, and high sample size requirement might make it prone to misuse....

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Detalles Bibliográficos

Principais autores:	Sandeep Grover, Fabiola Del Greco M., Inke R. König
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2018-09-01
Series:	Systematic Reviews
Assuntos:	Mendelian randomization Instrumental variable Observational epidemiology Genome-wide association study Summary data Pleiotropy
Acceso en liña:	http://link.springer.com/article/10.1186/s13643-018-0809-3
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