Cancer-associated fibroblasts in hepatocellular carcinoma: origins, heterogeneity, and therapeutic implications

Hepatocellular carcinoma (HCC) is a globally prevalent malignancy. This disease often progresses rapidly, resulting in many patients being diagnosed at a late stage, making early detection and intervention a major clinical challenge. Postoperative recurrence and metastasis rates remain significantly...

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Autori principali:	Xin Shi, Weixiong Zhu, Jianpeng Zhang, Chuanlei Fan, Jing Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-07-01
Serie:	Frontiers in Immunology
Soggetti:	hepatocellular carcinoma (HCC) cancer-associated fibroblasts (CAFs) tumor microenvironment (TME) therapeutic resistance immune evasion
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1620075/full
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