Cancer-associated fibroblasts at the crossroads of tumor progression and therapy resistance: from heterogeneity to precision reprogramming
Abstract Cancer-associated fibroblasts (CAFs) are pivotal regulators of the tumor microenvironment (TME), driving malignancy through extracellular matrix remodeling, paracrine and metabolic crosstalk, angiogenesis, fibrosis, and immune suppression. Emerging single-cell and spatial multi-omics have r...
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| Principais autores: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
SpringerOpen
2025-12-01
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| Serier: | Journal of the Egyptian National Cancer Institute |
| Fag: | |
| Online adgang: | https://doi.org/10.1186/s43046-025-00334-7 |
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