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Cancer-associated fibroblasts at the crossroads of tumor progression and therapy resistance: from heterogeneity to precision reprogramming

Abstract Cancer-associated fibroblasts (CAFs) are pivotal regulators of the tumor microenvironment (TME), driving malignancy through extracellular matrix remodeling, paracrine and metabolic crosstalk, angiogenesis, fibrosis, and immune suppression. Emerging single-cell and spatial multi-omics have r...

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Principais autores: Ravi Adusumalli, Rajkiran Reddy Banala
格式: Artigo
语言:Inglês
出版: SpringerOpen 2025-12-01
丛编:Journal of the Egyptian National Cancer Institute
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在线阅读:https://doi.org/10.1186/s43046-025-00334-7
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