Rotational restriction of nascent peptides as an essential element of co-translational protein folding: possible molecular players and structural consequences

Abstract Background A basic tenet of protein science is that all information about the spatial structure of proteins is present in their sequences. Nonetheless, many proteins fail to attain native structure upon experimental denaturation and refolding in vitro, raising the question of the specific r...

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Principais autores:	Irina Sorokina, Arcady Mushegian
格式:	Artigo
語言:	Inglês
出版:	BMC 2017-05-01
叢編:	Biology Direct
主題:	Protein folding Protein backbone twist Protein backbone torsion Peptide backbone twist Peptide backbone torsion Co-translational protein folding
在線閱讀:	http://link.springer.com/article/10.1186/s13062-017-0186-1
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