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IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model

BackgroundEfforts to control tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis (Mtb), have been hampered by the immense variability in protection from BCG vaccination. While BCG protects young children from some forms of TB disease, long-term protection against pulmonary disease i...

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Principais autores: Shelby D. Bradford, Kenneth J. Ryan, Ashley M. Divens, Jessica M. Povroznik, Sunilkanth Bonigala, Cory M. Robinson
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-02-01
Serier:Frontiers in Immunology
Fag:
interleukin-27
neonate
BCG
tuberculosis
vaccine
vaccination
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1217098/full
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