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RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cells

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with a poor response to current treatment regimens. The multifunctional DNA repair-redox signaling protein Ref-1 has a redox signaling function that activates several transcriptional factors (TFs) including NF-κB (RelA), STAT3,...

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Tallennettuna:
Päätekijät: Mahmut Mijit, Randall Wireman, Lee Armstrong, Silpa Gampala, Zonera Hassan, Christian Schneeweis, Guenter Schneider, Chi Zhang, Melissa L. Fishel, Mark R. Kelley
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2022-03-01
Sarja:Frontiers in Oncology
Aiheet:
pancreatic ductal adenocarcinoma (PDAC)
Ape1
transcriptional factors
relA
DNA repair
redox signaling
Linkit:https://www.frontiersin.org/articles/10.3389/fonc.2022.826617/full
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