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Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target

Abstract Background Pancreatic cancer is a complex disease with a desmoplastic stroma, extreme hypoxia, and inherent resistance to therapy. Understanding the signaling and adaptive response of such an aggressive cancer is key to making advances in therapeutic efficacy. Redox factor-1 (Ref-1), a redo...

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Principais autores: Silpa Gampala, Fenil Shah, Xiaoyu Lu, Hye-ran Moon, Olivia Babb, Nikkitha Umesh Ganesh, George Sandusky, Emily Hulsey, Lee Armstrong, Amber L. Mosely, Bumsoo Han, Mircea Ivan, Jing-Ruey Joanna Yeh, Mark R. Kelley, Chi Zhang, Melissa L. Fishel
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2021-08-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
scRNA-seq
Ref-1
Redox function
Metabolism
OXPHOS
Cancer associated fibroblasts (CAFs)
Acesso em linha:https://doi.org/10.1186/s13046-021-02046-x
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