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The CDK Inhibitor Dinaciclib Improves Cisplatin Response in Nonseminomatous Testicular Cancer: A Preclinical Study

Background: Most patients with testicular germ cell tumors (GCTs) are treated with cisplatin (CP)-based chemotherapy. However, some of them may develop CP resistance and therefore represent a clinical challenge. Cyclin-dependent kinase 5 (CDK5) is involved in chemotherapy resistance in different typ...

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Huvudupphov: Elisa Rossini, Mariangela Tamburello, Andrea Abate, Silvia Zini, Giovanni Ribaudo, Alessandra Gianoncelli, Stefano Calza, Francesca Valcamonico, Nazareno R. Suardi, Giuseppe Mirabella, Alfredo Berruti, Sandra Sigala
Materialtyp: Artigo
Språk:Inglês
Utgiven: MDPI AG 2024-02-01
Serie:Cells
Ämnen:
testicular cancer
cisplatin resistance
CDK inhibitors
dinaciclib
combined treatment
zebrafish xenograft
Länkar:https://www.mdpi.com/2073-4409/13/5/368
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