Comprehensive multi-omics analyses expose a precision therapy strategy that targets replication stress in hepatocellular carcinoma using WEE1 inhibition

Introduction: Hepatocellular carcinoma (HCC) is an extremely heterogeneous malignancy with a poor prognosis, highlighting the need to target specific vulnerabilities within the tumor during treatment. Objectives: This study employs multi-omics analysis techniques to provide novel insights into perso...

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Detalhes bibliográficos

Principais autores:	Xing Jia, Xingxin Zhu, Shinuo Chen, Qiongzi Qiu, Wenfeng Song, Shiyu Zhang, Haijiang Dong, Zequn Li, Suchen Bian, Hao Wu, Haojiang Dai, Cheng Jin, Mengqiao Zhou, Jun Chen, Zefeng Xuan, Pengfei Liu, Qiufang Zeng, Haiyang Xie, Shusen Zheng, Penghong Song
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-12-01
coleção:	Journal of Advanced Research
Assuntos:	Multi-omics Replication stress Adavosertib Oxaliplatin Precision medicine Hepatocellular carcinoma
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2090123225001146
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