Long-term exposure to PM2.5 exacerbates dopaminergic neuronal loss through CpG hypermethylation induced down-regulation of PINK1 and DJ-1 genes

Abstract To investigate whether airborne particle (PM2.5) aggravates Parkinson’s disease (PD) and alter expression of key PD-related genes by DNA methylation. Two groups of rats were exposed to either clean air or polluted air for 3, 6, and 12 months. The neurotoxin rotenone was injected intraperito...

Descripción completa

Detalles Bibliográficos

Autores principales:	Xiangnan Du, Longfei Guan, Chen Chen, Xuemei Wang, Xiaokun Geng
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-03-01
Colección:	Scientific Reports
Materias:	Parkinson’s disease PM2.5 PINK1 DJ-1 CpG hypermethylation
Acceso en línea:	https://doi.org/10.1038/s41598-025-89422-1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!