Long-term exposure to PM2.5 exacerbates dopaminergic neuronal loss through CpG hypermethylation induced down-regulation of PINK1 and DJ-1 genes
Abstract To investigate whether airborne particle (PM2.5) aggravates Parkinson’s disease (PD) and alter expression of key PD-related genes by DNA methylation. Two groups of rats were exposed to either clean air or polluted air for 3, 6, and 12 months. The neurotoxin rotenone was injected intraperito...
में बचाया:
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Portfolio
2025-03-01
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| श्रृंखला: | Scientific Reports |
| विषय: | |
| ऑनलाइन पहुंच: | https://doi.org/10.1038/s41598-025-89422-1 |
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