Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations

Abstract Vaults are massive ribonucleoprotein complexes, highly conserved and abundant in eukaryotic cells, yet with unclear function. Their thin-walled barrel-shape architecture is composed of two symmetrical, antiparallel half-shells, each containing 39 copies of the major vault protein (MVP). The...

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Hlavní autoři:	Fabio Lapenta, Karen Palacio-Rodriguez, Sergio Cruz-León, Simone Marrancone, Jana Aupič, Nils Marechal, Alexandre Durand, Dihia Moussaoui, Sonia Covaceuszach, Bhavani Gangupam, Claudia D’Ercole, Cristian Parra, Davide Cotugno, Giulia Tomaino, Paolo Tortora, Ario de Marco, Alberto Cassetta, Alessandra Magistrato, Gerhard Hummer
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-05-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-026-72674-4
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!