Structural flexibility of the human vault particle revealed by high-resolution cryo-EM and molecular dynamics simulations

Abstract Vaults are massive ribonucleoprotein complexes, highly conserved and abundant in eukaryotic cells, yet with unclear function. Their thin-walled barrel-shape architecture is composed of two symmetrical, antiparallel half-shells, each containing 39 copies of the major vault protein (MVP). The...

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主要な著者:	Fabio Lapenta, Karen Palacio-Rodriguez, Sergio Cruz-León, Simone Marrancone, Jana Aupič, Nils Marechal, Alexandre Durand, Dihia Moussaoui, Sonia Covaceuszach, Bhavani Gangupam, Claudia D’Ercole, Cristian Parra, Davide Cotugno, Giulia Tomaino, Paolo Tortora, Ario de Marco, Alberto Cassetta, Alessandra Magistrato, Gerhard Hummer
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2026-05-01
シリーズ:	Nature Communications
オンライン･アクセス:	https://doi.org/10.1038/s41467-026-72674-4
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