Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

Abstract Background Activation of microglia, the resident immune cells of the central nervous system, is a prominent pathological hallmark of Alzheimer’s disease (AD). However, the gene expression changes underlying microglia activation in response to tau pathology remain elusive. Furthermore, it is...

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Hauptverfasser:	Hong Wang, Yupeng Li, John W. Ryder, Justin T. Hole, Philip J. Ebert, David C. Airey, Hui-Rong Qian, Benjamin Logsdon, Alice Fisher, Zeshan Ahmed, Tracey K. Murray, Annalisa Cavallini, Suchira Bose, Brian J. Eastwood, David A. Collier, Jeffrey L. Dage, Bradley B. Miller, Kalpana M. Merchant, Michael J. O’Neill, Ronald B. Demattos
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2018-12-01
Schriftenreihe:	Molecular Neurodegeneration
Schlagworte:	Microglia rTg4510 Tauopathy RNAseq Neuroinflammation Alzheimer’s disease
Online-Zugang:	http://link.springer.com/article/10.1186/s13024-018-0296-y
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