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Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer’s disease: a preclinical study in rTg4510 mice

Abstract Background The lack of effective treatment options for Alzheimer’s disease (AD) is of momentous societal concern. Synaptic loss is the hallmark of AD that correlates best with impaired memory and occurs early in the disease process, before the onset of clinical symptoms. We have developed a...

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Principais autores: Joshua B. Foster, Rashelle Lashley, Fangli Zhao, Xueqin Wang, Nydia Kung, Candice C. Askwith, Lin Lin, Michael W. Shultis, Kevin J. Hodgetts, Chien-Liang Glenn Lin
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-08-01
coleção:Alzheimer’s Research & Therapy
Assuntos:
Alzheimer’s disease
Glutamate transporter EAAT2
Tauopathy
Small-molecule
rTg4510
Acesso em linha:http://link.springer.com/article/10.1186/s13195-019-0530-z
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