Exploration of the skeletal phenotype of the Col1a1+/Mov13 mouse model for haploinsufficient osteogenesis imperfecta type 1

IntroductionOsteogenesis Imperfecta is a rare genetic connective tissue disorder, characterized by skeletal dysplasia and fragile bones. Currently only two mouse models have been reported for haploinsufficient (HI) mild Osteogenesis Imperfecta (OI); the Col1a1+/Mov13 (Mov13) and the Col1a1+/-365 mou...

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Detalhes bibliográficos

Principais autores:	Lauria Claeys, Lidiia Zhytnik, Lisanne E. Wisse, Huib W. van Essen, E. Marelise W. Eekhoff, Gerard Pals, Nathalie Bravenboer, Dimitra Micha
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-03-01
coleção:	Frontiers in Endocrinology
Assuntos:	Mov13 osteogenesis imperfecta Col1a1 haploinsufficient bone collagen
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1145125/full
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