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Destabilization of Eukaryote mRNAs by 5′ Proximal Stop Codons Can Occur Independently of the Nonsense-Mediated mRNA Decay Pathway

In eukaryotes, the binding of poly(A) binding protein (PAB) to the poly(A) tail is central to maintaining mRNA stability. PABP interacts with the translation termination apparatus, and with eIF4G to maintain 3′−5′ mRNA interactions as part of an mRNA closed loop. It is however uncl...

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Principais autores: Barbara Gorgoni, Yun-Bo Zhao, J. Krishnan, Ian Stansfield
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2019-07-01
סדרה:Cells
נושאים:
translation
mRNA decay
mathematical modelling
translational regulation
<i>Saccharomyces cerevisiae</i>
גישה מקוונת:https://www.mdpi.com/2073-4409/8/8/800
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