Destabilization of Eukaryote mRNAs by 5′ Proximal Stop Codons Can Occur Independently of the Nonsense-Mediated mRNA Decay Pathway

In eukaryotes, the binding of poly(A) binding protein (PAB) to the poly(A) tail is central to maintaining mRNA stability. PABP interacts with the translation termination apparatus, and with eIF4G to maintain 3′−5′ mRNA interactions as part of an mRNA closed loop. It is however uncl...

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Autores principales:	Barbara Gorgoni, Yun-Bo Zhao, J. Krishnan, Ian Stansfield
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2019-07-01
Colección:	Cells
Materias:	translation mRNA decay mathematical modelling translational regulation <i>Saccharomyces cerevisiae</i>
Acceso en línea:	https://www.mdpi.com/2073-4409/8/8/800
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