Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response.

Insulin-secreting β-cells are functionally heterogeneous. Whether there exist cells driving the first-phase calcium response in individual islets, has not been examined. We examine "first responder" cells, defined by the earliest [Ca2+] response during first-phase [Ca2+] elevation, distinct from pre...

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Bibliografski detalji

Glavni autori:	Vira Kravets, JaeAnn M Dwulet, Wolfgang E Schleicher, David J Hodson, Anna M Davis, Laura Pyle, Robert A Piscopio, Maura Sticco-Ivins, Richard K P Benninger
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2022-09-01
Serija:	PLoS Biology
Online pristup:	https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001761&type=printable
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