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Small subpopulations of β-cells do not drive islet oscillatory [Ca2+] dynamics via gap junction communication.

The islets of Langerhans exist as multicellular networks that regulate blood glucose levels. The majority of cells in the islet are excitable, insulin-producing β-cells that are electrically coupled via gap junction channels. β-cells are known to display heterogeneous functionality. However, due to...

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Váldodahkkit: JaeAnn M Dwulet, Jennifer K Briggs, Richard K P Benninger
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Public Library of Science (PLoS) 2021-05-01
Ráidu:PLoS Computational Biology
Liŋkkat:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008948&type=printable
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