Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons

Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral sclerosis, frontotemporal dementia, and glaucoma, supporting its role in the etiology of neurodegenerative...

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Principais autores:	Zachary M. Augur, Garrett M. Fogo, Mason R. Arbery, Andrew M. Stern, Courtney R. Benoit, Yi-Chen Hsieh, Tracy L. Young-Pearse
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-09-01
Series:	Acta Neuropathologica Communications
Assuntos:	Optineurin Autophagy Tau Alzheimer’s disease Clusterin
Acceso en liña:	https://doi.org/10.1186/s40478-025-02103-y
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