Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets

Alzheimer's disease (AD), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in the brain. However, more than half of patients also exhibit aggregates of the protein TDP-43 as a secondary pathology. The presence of...

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Główni autorzy:	Vaishnavi S. Jadhav, Jade G. Stair, Randall J. Eck, Samuel N. Smukowski, Heather N. Currey, Laura Garcia Toscano, Joshua C. Hincks, Caitlin S. Latimer, Paul N. Valdmanis, Brian C. Kraemer, Nicole F. Liachko
Format:	Artigo
Język:	Inglês
Wydane:	Elsevier 2024-04-01
Seria:	Neurobiology of Disease
Hasła przedmiotowe:	Tau TDP-43 Alzheimer's disease C. elegans Neurodegeneration Transcriptomics
Dostęp online:	http://www.sciencedirect.com/science/article/pii/S0969996124000408
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