Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets

Alzheimer's disease (AD), the most common aging-associated neurodegenerative dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in the brain. However, more than half of patients also exhibit aggregates of the protein TDP-43 as a secondary pathology. The presence of...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Vaishnavi S. Jadhav, Jade G. Stair, Randall J. Eck, Samuel N. Smukowski, Heather N. Currey, Laura Garcia Toscano, Joshua C. Hincks, Caitlin S. Latimer, Paul N. Valdmanis, Brian C. Kraemer, Nicole F. Liachko
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2024-04-01
Sarja:	Neurobiology of Disease
Aiheet:	Tau TDP-43 Alzheimer's disease C. elegans Neurodegeneration Transcriptomics
Linkit:	http://www.sciencedirect.com/science/article/pii/S0969996124000408
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