Caspase 3 exhibits a yeast metacaspase proteostasis function that protects mitochondria from toxic TDP43 aggregates

Caspase 3 activation is a hallmark of cell death and there is a strong correlation between elevated protease activity and evolving pathology in neurodegenerative disease, such as amyotrophic lateral sclerosis (ALS). At the cellular level, ALS is characterized by protein aggregates and inclusions, co...

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Autori principali:	Steve Brunette, Anupam Sharma, Ryan Bell, Lawrence Puente, Lynn A Megeney
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Shared Science Publishers OG 2023-07-01
Serie:	Microbial Cell
Soggetti:	caspase metacaspase yeast tdp43 proteostasis protein aggregation
Accesso online:	http://microbialcell.com/researcharticles/2023a-brunette-microbial-cell/
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