CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation

Hyperphosphorylated TAR DNA-binding protein 43 (TDP-43) aggregates in the cytoplasm of neurons is the neuropathological hallmark of amyotrophic lateral sclerosis (ALS) and a group of neurodegenerative diseases collectively referred to as TDP-43 proteinopathies that includes frontotemporal dementia,...

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Principais autores:	Vivian I. Ko, Kailee Ong, Don W. Cleveland, Haiyang Yu, John M. Ravits
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-06-01
Colecção:	Neurobiology of Disease
Assuntos:	Amyotrophic lateral sclerosis TDP-43 proteinopathies Phosphorylation TAR DNA-binding protein (TDP-43) Casein kinase 1 delta Casein kinase 1 epsilon
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996124001153
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