Fast-tracking antibody maturation using a B cell-based display system

Affinity maturation, an essential component of antibody engineering, is crucial for developing therapeutic antibodies. Cell display system coupled with somatic hypermutation (SHM) initiated by activation-induced cytidine deaminase (AID) is a commonly used technique for affinity maturation. AID intro...

Descripció completa

Dades bibliogràfiques

Autors principals:	Hitomi Masuda, Atsushi Sawada, Shu-ichi Hashimoto, Kanako Tamai, Ke-Yi Lin, Naoto Harigai, Kohei Kurosawa, Kunihiro Ohta, Hidetaka Seo, Hiroshi Itou
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2022-12-01
Col·lecció:	mAbs
Matèries:	Affinity maturation DT40 somatic hypermutation activation-induced cytidine deaminase hotspot coldspot
Accés en línia:	https://www.tandfonline.com/doi/10.1080/19420862.2022.2122275
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!