Fast-tracking antibody maturation using a B cell-based display system

Affinity maturation, an essential component of antibody engineering, is crucial for developing therapeutic antibodies. Cell display system coupled with somatic hypermutation (SHM) initiated by activation-induced cytidine deaminase (AID) is a commonly used technique for affinity maturation. AID intro...

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Hlavní autoři:	Hitomi Masuda, Atsushi Sawada, Shu-ichi Hashimoto, Kanako Tamai, Ke-Yi Lin, Naoto Harigai, Kohei Kurosawa, Kunihiro Ohta, Hidetaka Seo, Hiroshi Itou
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2022-12-01
Edice:	mAbs
Témata:	Affinity maturation DT40 somatic hypermutation activation-induced cytidine deaminase hotspot coldspot
On-line přístup:	https://www.tandfonline.com/doi/10.1080/19420862.2022.2122275
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