Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5

Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery. Herein, we reported the design and synthe...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, Rong Huang
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2021-09-01
Цуврал:	Acta Pharmaceutica Sinica B
Нөхцлүүд:	Protein arginine methyltransferase 5 Protein arginine methyltransferase 4 Bisubstrate analogue Protein arginine methyltransferase Bisubstrate inhibitor
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2211383520307656
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!