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Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5

Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery. Herein, we reported the design and synthe...

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Principais autores: Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, Rong Huang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-09-01
Serier:Acta Pharmaceutica Sinica B
Fag:
Protein arginine methyltransferase 5
Protein arginine methyltransferase 4
Bisubstrate analogue
Protein arginine methyltransferase
Bisubstrate inhibitor
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211383520307656
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