Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5

Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug discovery. Herein, we reported the design and synthe...

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מידע ביבליוגרפי

Principais autores:	Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, Rong Huang
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2021-09-01
סדרה:	Acta Pharmaceutica Sinica B
נושאים:	Protein arginine methyltransferase 5 Protein arginine methyltransferase 4 Bisubstrate analogue Protein arginine methyltransferase Bisubstrate inhibitor
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2211383520307656
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!