Radioiodinated Tau Imaging Agent III Molecular Modeling, Synthesis, and Evaluation of a New Tau Imaging Agent, [¹²⁵I]ISAS in Post-Mortem Human Alzheimer’s Disease Brain

Using a molecular modeling approach for Tau-binding sites, we modified our previously reported imaging agent, [¹²⁵I]INFT, for the potential improvement of binding properties to Tau in an Alzheimer’s disease (AD) brain. Two new derivatives, namely [¹²⁵I]ISAS and [¹²⁵I...

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Autori principali:	Stephanie A. Sison, Cayz G. Paclibar, Christopher Liang, Jogeshwar Mukherjee
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2024-07-01
Serie:	Molecules
Soggetti:	[<sup>125</sup>I]ISAS [<sup>125</sup>I]INFT [<sup>125</sup>I]IPPI post-mortem human Tau Alzheimer’s disease neurofibrillary tangles
Accesso online:	https://www.mdpi.com/1420-3049/29/14/3308
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