Activity of DNA- and RNA-Guided Prokaryotic Argonautes in Human Mitochondria

Precise manipulation of mitochondrial DNA (mtDNA) by CRISPR-Cas systems remains challenging, largely due to inefficient import of guide RNAs, motivating the exploration of alternative programmable nucleases. Here, we show that prokaryotic Argonaute nucleases (pAgos) of various classes can be efficie...

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主要な著者:	Beatrisa Rimskaya, Ekaterina Kropocheva, Iaroslava Ponomareva, Lada Karchemkina, Lidiya Lisitskaya, Daria Gelfenbein, Egor Ulashchik, Vadim Shmanai, Andrey Kulbachinskiy, Ilya Mazunin
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2026-06-01
シリーズ:	Cells
主題:	prokaryotic argonautes mitochondria D-loop mtDNA copy number
オンライン･アクセス:	https://www.mdpi.com/2073-4409/15/12/1129
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