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Activity of DNA- and RNA-Guided Prokaryotic Argonautes in Human Mitochondria

Precise manipulation of mitochondrial DNA (mtDNA) by CRISPR-Cas systems remains challenging, largely due to inefficient import of guide RNAs, motivating the exploration of alternative programmable nucleases. Here, we show that prokaryotic Argonaute nucleases (pAgos) of various classes can be efficie...

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Autori principali: Beatrisa Rimskaya, Ekaterina Kropocheva, Iaroslava Ponomareva, Lada Karchemkina, Lidiya Lisitskaya, Daria Gelfenbein, Egor Ulashchik, Vadim Shmanai, Andrey Kulbachinskiy, Ilya Mazunin
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2026-06-01
Serie:Cells
Soggetti:
prokaryotic argonautes
mitochondria
D-loop
mtDNA copy number
Accesso online:https://www.mdpi.com/2073-4409/15/12/1129
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