XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways.
Loss of the XPF-ERCC1 endonuclease causes a dramatic phenotype that results in progeroid features associated with liver, kidney and bone marrow dysfunction. As this nuclease is involved in multiple DNA repair transactions, it is plausible that this severe phenotype results from the simultaneous inac...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science (PLoS)
2020-04-01
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| Seria: | PLoS Genetics |
| Dostęp online: | https://doi.org/10.1371/journal.pgen.1008555 |
| Etykiety: |
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