Analysis of translatomic changes in the Ubqln2P497S model of ALS reveals that motor neurons express muscle-associated genes in non-disease states

IntroductionAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressively worsening motor symptoms that lead to eventual fatal paralysis. The number of gene mutations associated with ALS have increased dramatically in recent years, suggesting heterogen...

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Egile Nagusiak:	Wesley M. Stansberry, Natalie C. Fiur, Melissa M. Robins, Brian A. Pierchala
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2024-11-01
Saila:	Frontiers in Neurology
Gaiak:	amyotrophic lateral sclerosis UBQLN2 proteostasis neuromuscular disease motor neuron disease frontotemporal dementia
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fneur.2024.1491415/full
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