Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS/FTD
Ubiquilin-2 (UBQLN2) is a ubiquitin (Ub)-binding shuttle protein that is mutated in X-linked forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS/FTD-linked mutations in UBQLN2 disrupt its conformation, increasing its tendency to form cytoplasmic aggregates that may di...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2026-01-01
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| coleção: | Frontiers in Molecular Neuroscience |
| Assuntos: | |
| Acesso em linha: | https://www.frontiersin.org/articles/10.3389/fnmol.2025.1720347/full |
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