Atomic-resolution mapping of transcription factor-DNA interactions by femtosecond laser crosslinking and mass spectrometry

Cross-linking mass spectrometry (MS) is an important tool in structural biology, but its application to protein-DNA complexes has been hampered by low cross-linking efficiency. Here, the authors develop a femtosecond UV-laser induced cross-linking MS workflow to map protein-DNA interactions in vitro...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Alexander Reim, Roland Ackermann, Jofre Font-Mateu, Robert Kammel, Miguel Beato, Stefan Nolte, Matthias Mann, Christoph Russmann, Michael Wierer
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2020-06-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-020-16837-x
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