Targeting Sigma-1 and Sigma-2 Receptors in Neuropathic Pain: Pharmacology, Ligand Development, and Translational Progress

Background: Neuropathic pain remains a major unmet clinical challenge. Growing evidence identifies sigma receptors (σRs) as pivotal intracellular modulators of maladaptive stress signaling, positioning them as promising non-opioid targets for chronic pain management. Notably, despite the pleiotropic...

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Bibliografiska uppgifter

Huvudupphov:	Carlo Reale, Giuliana Costanzo, Lorella Pasquinucci, Carmela Parenti
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2026-03-01
Serie:	Brain Sciences
Ämnen:	sigma receptors neuroinflammation chronic pain hyperalgesia allodynia
Länkar:	https://www.mdpi.com/2076-3425/16/4/371
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