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TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

TGFβ has a role in cancer immunosuppression but the exact mechanisms haven’t been fully elucidated. Here, using mouse models deficient in TGFβ-signaling, the authors show that loss of ALK5 in CD8 + T cells enhances their tumour trafficking and cytotoxicity suggesting that ALK5 inhibitors may have cl...

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Principais autores: Andrew J. Gunderson, Tomoko Yamazaki, Kayla McCarty, Nathaniel Fox, Michaela Phillips, Alejandro Alice, Tiffany Blair, Mark Whiteford, David O’Brien, Rehan Ahmad, Maria X. Kiely, Amanda Hayman, Todd Crocenzi, Michael J. Gough, Marka R. Crittenden, Kristina H. Young
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2020-04-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-020-15404-8
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