Ethylenediaminetetraacetic Acid (EDTA)-Decalcified, Formalin-Fixed Paraffin-Embedded (FFPE) Tumor Tissue Shows Comparable Quality and Quantity of DNA to Non-Decalcified Tissue in Next-Generation Sequencing (NGS)

<b>Background:</b> Bone tissue decalcification is essential for histopathological evaluation, but conventional methods using inorganic acids degrade nucleic acids, limiting molecular testing. EDTA is known to better preserve DNA, but its suitability for next-generation sequencing (NGS) in clinical s...

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Manylion Llyfryddiaeth

Prif Awduron:	Francis Hong Xin Yap, Jen-Hwei Sng, Jeremy Wee Kiat Ng, Hanis Abdul Kadir, Pei Yi Chan, Timothy Kwang Yong Tay
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	MDPI AG 2025-09-01
Cyfres:	Journal of Molecular Pathology
Pynciau:	Ethylenediaminetetraacetic Acid (EDTA) next-generation sequencing (NGS) decalcification
Mynediad Ar-lein:	https://www.mdpi.com/2673-5261/6/3/21
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!