NF-E2-related factor 1 suppresses the expression of a spermine oxidase and the production of highly reactive acrolein

Abstract Polyamines (putrescine, spermidine, and spermine) are among the most abundant intracellular small molecular metabolites, with concentrations at the mM level. The ratios of these three molecules remain constant under physiological conditions. Stress (i.e. polyamine overload, oxidative stress...

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Hlavní autoři:	Tomoaki Hirakawa, Megumi Taniuchi, Yoko Iguchi, Sudarma Bogahawaththa, Kiko Yoshitake, Shanika Werellagama, Takeshi Uemura, Tadayuki Tsujita
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-04-01
Edice:	Scientific Reports
Témata:	Spermine oxidase Spermidine NRF1 Acrolein Polyamine Polyamine imbalance
On-line přístup:	https://doi.org/10.1038/s41598-025-96388-7
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