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Identification and Characterization of Novel Small-Molecule SMOX Inhibitors

The major intracellular polyamines spermine and spermidine are abundant and ubiquitous compounds that are essential for cellular growth and development. Spermine catabolism is mediated by spermine oxidase (SMOX), a highly inducible flavin-dependent amine oxidase that is upregulated during excitotoxi...

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Principais autores: Amelia B. Furbish, Ahmed S. Alford, Pieter Burger, Yuri K. Peterson, Tracy Murray-Stewart, Robert A. Casero, Patrick M. Woster
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-08-01
coleção:Medical Sciences
Assuntos:
spermine oxidase
polyamines
oxidative stress
acrolein
excitotoxicity
polyamine oxidase
Acesso em linha:https://www.mdpi.com/2076-3271/10/3/47
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