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NF-E2-related factor 1 suppresses the expression of a spermine oxidase and the production of highly reactive acrolein

Abstract Polyamines (putrescine, spermidine, and spermine) are among the most abundant intracellular small molecular metabolites, with concentrations at the mM level. The ratios of these three molecules remain constant under physiological conditions. Stress (i.e. polyamine overload, oxidative stress...

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Principais autores: Tomoaki Hirakawa, Megumi Taniuchi, Yoko Iguchi, Sudarma Bogahawaththa, Kiko Yoshitake, Shanika Werellagama, Takeshi Uemura, Tadayuki Tsujita
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-04-01
Serier:Scientific Reports
Fag:
Spermine oxidase
Spermidine
NRF1
Acrolein
Polyamine
Polyamine imbalance
Online adgang:https://doi.org/10.1038/s41598-025-96388-7
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