XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations in XIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using gene-targeted mice, we show that loss of XIAP...

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Bibliografiske detaljer

Principais autores:	Monica Yabal, Nicole Müller, Heiko Adler, Nathalie Knies, Christina J. Groß, Rune Busk Damgaard, Hirokazu Kanegane, Marc Ringelhan, Thomas Kaufmann, Mathias Heikenwälder, Andreas Strasser, Olaf Groß, Jürgen Ruland, Christian Peschel, Mads Gyrd-Hansen, Philipp J. Jost
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2014-06-01
Serier:	Cell Reports
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2211124714003830
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