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Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

Abstract Background The role of the innate immune system in Alzheimer’s disease (AD) and neurodegenerative disease susceptibility has recently been highlighted in genetic studies. However, we do not know whether risk for inflammatory disease predisposes unaffected individuals to late-life cognitive...

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Principais autores: Daniel Felsky, Ellis Patrick, Julie A. Schneider, Sara Mostafavi, Chris Gaiteri, Nikolaos Patsopoulos, David A. Bennett, Philip L. De Jager
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-07-01
Serier:Molecular Neurodegeneration
Fag:
Genomics
Alzheimer’s disease
Microglia
Inflammation
Polygenic score
Innate immunity
Online adgang:http://link.springer.com/article/10.1186/s13024-018-0272-6
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