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Synthesis of the polyketide section of seragamide A and related cyclodepsipeptides via Negishi cross coupling

The synthesis of the polyketide section present in the potently cytotoxic marine cyclodepsipeptide jasplakinolide and related natural products, geodiamolides and seragamides, is reported. The key step is a Negishi cross coupling of (R)-(3-methoxy-2-methyl-3-oxopropyl)zinc(II) bromide and an (E)-iodo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jan Hendrik Lang, Thomas Lindel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Beilstein-Institut 2019-02-01
Cyfres:Beilstein Journal of Organic Chemistry
Pynciau:
Mynediad Ar-lein:https://doi.org/10.3762/bjoc.15.53
Tagiau: Ychwanegu Tag
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