Silencing of the von Willebrand factor gene in proatherothrombotic APOE∗3-Leiden.CETP transgenic mice

Background: Elevated von Willebrand factor (VWF) levels correlate with higher risk of atherosclerosis-related arterial thrombosis (atherothrombosis). Silencing the VWF gene via small-interfering RNAs (siRNAs) could mitigate this risk. Previous studies successfully delivered siRNA to the endothelium...

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Bibliografiske detaljer

Principais autores:	Yvonne K. Jongejan, Richard J. Dirven, Elisa Schrader Echeverri, Anke J.L. de Jong, Amanda C.M. Pronk, Sander Kooijman, Patrick C.N. Rensen, James E. Dahlman, Jeroen C.J. Eikenboom, Bart J.M. van Vlijmen
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2025-01-01
Serier:	Research and Practice in Thrombosis and Haemostasis
Fag:	atherothrombosis hypercholesterolemia mouse model siRNA von Willebrand factor
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2475037925000238
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