Silencing of the von Willebrand factor gene in proatherothrombotic APOE∗3-Leiden.CETP transgenic mice

Background: Elevated von Willebrand factor (VWF) levels correlate with higher risk of atherosclerosis-related arterial thrombosis (atherothrombosis). Silencing the VWF gene via small-interfering RNAs (siRNAs) could mitigate this risk. Previous studies successfully delivered siRNA to the endothelium...

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Autori principali:	Yvonne K. Jongejan, Richard J. Dirven, Elisa Schrader Echeverri, Anke J.L. de Jong, Amanda C.M. Pronk, Sander Kooijman, Patrick C.N. Rensen, James E. Dahlman, Jeroen C.J. Eikenboom, Bart J.M. van Vlijmen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-01-01
Serie:	Research and Practice in Thrombosis and Haemostasis
Soggetti:	atherothrombosis hypercholesterolemia mouse model siRNA von Willebrand factor
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2475037925000238
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